Chemists Synthesize Carboxypolyamines and Design Inhibitors of Bacterial Polyamine Enzyme
Researchers report a convenient synthesis of carboxypolyamine substrates and hydroxylamine-containing analogs designed to selectively inhibit carboxyspermidine decarboxylase in bacterial polyamine biosynthesis. Biogenic polyamines such as spermidine and spermine are small organic polycations that are vitally important across all domains of life Recent studies have shown that polyamine biosynthesis has undergone…